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Technology
Technology Summary
Gene Activated Matrix (GAM) technology provides a therapeutic level of protein synthesis at the site of tissue injury that is unsurpassed by other forms of gene or protein delivery. The technology is distinctive in that it is an immobilized form of gene delivery that allows precise control of gene dispersion.
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Repair of an acute injury occurs in a complex but ordered sequence: (a) control of hemorrhage, (b) formation of granulation tissue, and (c) tissue healing. Participating cells include platelets, inflammatory cells (stage a), fibroblasts, endothelial cells, pericytes, macrophages and tissue-specific progenitor cells (stage b). These cells respond to extracellular cytokines, growth factors and hormones, which govern the cell proliferation, migration and differentiation events that characterize the process of tissue repair.
Essentially, GAM consists of a gene encoding a growth factor formulated within a biocompatible matrix. The Company’s studies have shown that proliferative cells migrate into the GAM, take up the immobilized gene and transiently express the coded protein. Compared with topical protein application, this in situ expression method significantly enhances the availability of therapeutic protein to the cells performing tissue repair. The simple application method involves placement of a GAM reagent onto a wound site.
TRC holds controlling intellectual property rights and all scientific “know how” related to the GAM technology.
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